The study was undertaken with an aim to formulate effervescent tablet of sildenafil citrate and aspirin in combination to achieve the immediate release and fast action of sildenafil citrate on the body with shorter period of the time and to overcome the side effect of the sildenafil citrate by simultaneous release of aspirin. A 32 full factorial design was applied and it revealed that the bicarbonate source (X1) and concentration of binder (X2) significantly affected the independent variables effervescence time (Y1) and hardness (Y2). The optimized formulation having citric acid 23.65 %, tartric acid 6.30 %, sodium bicarbonate 37.85 %, potassium bicarbonate 12.61 % with binder concentration 2% and hardness adjusted to 3 kg/cm2. From among the 9 batches (D1 – D9) the D3 batch have desirable property, less effervescence time, enough hardness and immediate release profile.