British Journal of Medical and Health Research BJMHR 2394-2967 BJMHR0202001 Folic Acid and Vitamin B Complex Improves Quality of Life in Hepatitis C Infected Patients Treated with Peginterferon and Ribavirin Ashoush Nermeen El-Hamamsy Manal Schaalan Mona Ahmed Osama Elmazar Mohey Badary Osama Faculty Of Pharmacy, The British University In Egypt Faculty Of Pharmacy, Ain Shams University Faculty Of Pharmacy, Misr International University Faculty Of Medicine, Ain Shams University, Cairo, Egyp 02 01 2015 2 2

Pegylated-interferon α-2a and ribavirin (PIFN/RBV), the current standard treatment for hepatitis C virus (HCV) infection in Egypt, is frequently associated with hematological adverse effects, leading to high treatment discontinuation rates. The objective of the present study is to explore the effectiveness of intervening with folic acid (F) and/or vitamin B complex (B) compared with placebo (C) in HCV-treatment Egyptian patients for the management of treatment-induced deterioration of health related quality of life (HRQOL) as well as hematological parameter. In a randomized controlled trial, one hundred and sixty subjects were randomly assigned to receive PIFN/RBV in addition to BF, B, F, or C. Blood samples were collected at different time points during 48 weeks and at 12 and 24 weeks post treatment for complete blood count and for HCV RNA real time PCR. Short form SF 36V2 questionnaire were used to assess HRQOL at various time during and post treatment. Egyptian HCV patients treated with PIFN/RBV showed deterioration of HRQOL which were correlated with deterioration in the measured hematological parameter. Supplementation with vitamin B complex plus folic acid significantly (P

 Hepatitis C virus Quality of life Folic acid Vitamin B complex Peginterferon Ribavirin.